Studies on Neoplasms with the Aid of Radioactive Phosphorus. Ii. the Phosphorus Metabolism of the Nucleoprotein, Phospholipid and Acid Soluble Fractions of Normal and Leukemic Mice.

نویسندگان

  • L W Tuttle
  • L A Erf
  • J H Lawrence
چکیده

Previous studies (1, 2) have shown that the phosphorus metabolism of mouse tissues is markedly altered by leukemic infiltration, the absorption and retention of radio-phosphorus being increased in the tissues of leukemic animals. The present work goes one step further in elucidating the seat of this altered phosphorus metabolism by fractionating the tissues into the three broad groups of biologically active phosphorus compounds: the phospholipid, nucleoprotein, and acid soluble fractions.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Phosphorus Turnover of Carcinoma of the Human Stomach as Measured with Radioactive Phosphorus.

The phosphorus turnover of tumors has been widely studied in animals and has been found to be higher than in normal tissues. Several blood dyscrasias have also been investigated extensively (1-3). The high uptake of radiophosphorus by leukemic cells and by red cells in polycythemia vera has been applied to the treatment of these diseases (4, 5). Low-Beer and collaborators have observed an incre...

متن کامل

P32 Uptake by Nuclei

1. A method for isolating nuclei in quantity from mammalian tissues is described. 2. The rate of uptake of radioactive phosphorus by nuclei is found to be quite rapid. The phosphorus was shown not to be taken up by exchange. 3. Nuclei of tumors accumulate more radioactive phosphorus than normal liver nuclei. This was shown to be due to mitotic activity and not a form of metabolism peculiar to t...

متن کامل

The effect of poliomyelitis virus type I (Mahoney strain) on the phospholipid metabolism of the HeLa cell.

There have been many investigations on the uptake of radioactive phosphorus by viral infected cells (1, 2), but the number of studies in which cells of animal origin are employed are few. To our knowledge, there are no studies on the effects of poliomyelitis virus on phosphorus metabolism in the HeLa cell. However, this cell has been successfully infected by the poliomyelitis virus (3, 4). In t...

متن کامل

تغییرات فسفر قابل‌جذب و شکل‌های فسفر معدنی بومی پس از غرقاب در خاک‌های شالیزاری شمال ایران

Phosphorus behavior in waterlogged soils is significantly different from non-waterlogged soils. Changes in available phosphorus and inorganic phosphorus fractions after waterlogging in the paddy soils of north of Iran were studied in a laboratory research. A factorial experiment in a completely randomized design with two replications was performed with factors of soil at 14 levels (10 alkaline-...

متن کامل

Phosphorus Metabolism of Neoplastic Tissues (mammary Carcinoma, Lymphoma, Lymphosarcoma) as Indicated by Radioactive Phosphorus

In previous studies from these laboratories, radioactive phosphorus was used to determine the rate of phospholipid turnover in 4 types of transplantable tumors: a mammary carcinoma, a lymphoma, a lymphosarcoma, and sarcoma 180 (1, 2 ) . Some distinctive features of the metabolism of these neoplastic tissues were described: (a) the fact that their phospholipid turnover bears a greater resemblanc...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The Journal of clinical investigation

دوره 20 1  شماره 

صفحات  -

تاریخ انتشار 1941